With a little rubber a secretary may rub out (5)
I believe the answer is:
erase
'rub out' is the definition.
(I know that rub out can be written as erase)
'with a little rubber a secretary' is the wordplay.
'with' says the answer is hidden in the clue.
'ERASE' can be found hidden inside 'little rubber a secretary'.
'may' acts as a link.
(Other definitions for erase that I've seen before include "Delete" , "score" , "Put out of mind" , "Remove all traces of" , "Remove permanently" .)