With each twist it hurts (4)
I believe the answer is:
ache
'it hurts' is the definition.
(I've seen this in another clue)
'with each twist' is the wordplay.
'each' anagrams to 'ACHE'.
But, I am not sure how the anagram is indicated.
Can you help me to learn more?
(Other definitions for ache that I've seen before include "Dull throbbing pain" , "burn" , "Play up" , "Long ? pain" , "painful" .)