With hearty Jethroe, I have to do well (6)
I believe the answer is:
thrive
'do well' is the definition.
(to thrive is to succeed or develop well)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for thrive that I've seen before include "Be successful" , "Grow vigorously, flourish" , "Grow strongly" , "Succeed" , "Hit rev in order to prosper" .)