With men around, she needs help (6)
I believe the answer is:
maiden
'with men' is the definition.
Although both the answer and definition are singular nouns, I don't see how they can define each other.
'around she needs help' is the wordplay.
'around' is an insertion indicator.
'she' becomes 'De'.
'needs help' becomes 'main' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'de' inserted inside 'main' is 'MAIDEN'.
Can you help me to learn more?
(Other definitions for maiden that I've seen before include "Spinster" , "To the rear (of a ship)" , "Female" , "Dotty over" , "Miss" .)