With misgivings, like one in a French cathedral city (8)
I believe the answer is:
uneasily
'with misgivings' is the definition.
'like one in a french cathedral city' is the wordplay.
'like' becomes 'as'.
'one' becomes 'i' (Roman numeral).
'in' is an insertion indicator.
'a french' becomes 'un' ('a' in French).
'cathedral city' becomes 'ely' (I've seen this before).
'as'+'i'='asi'
'un'+'ely'='unely'
'asi' inserted into 'unely' is 'UNEASILY'.
(Other definitions for uneasily that I've seen before include "With anxiety or apprehension" , "In nervous way" , "In apprehensive manner" , "In worried way, lacking in confidence" , "Hardly so, you might think" .)