Without Doctor Andrew again (4)
I believe the answer is:
anew
'again' is the definition.
(I've seen this before)
'without doctor andrew' is the wordplay.
'without' is a deletion indicator.
'doctor' becomes 'dr' ('Dr' can be a synonym of 'doctor').
'andrew' with 'dr' taken away is 'ANEW'.
(Other definitions for anew that I've seen before include "Once more (poetic)" , "Again but differently" , "Afresh" , "Wane in a different way, again" , "From the beginning again" .)