Woman in charge in Italian city (8)
I believe the answer is:
veronica
'woman' is the definition.
'in charge in italian city' is the wordplay.
'in charge' becomes 'ic'.
'in' means one lot of letters goes inside another.
'italian city' becomes 'verona' (I've seen this before).
'ic' inserted into 'verona' is 'VERONICA'.
(Other definitions for veronica that I've seen before include "Plant with spikes of blue or purple" , "Blue-flowered plant in a cover, oddly" , "Woman" , "Plant of the foxglove family in a cover, oddly" , "Plant also called speedwell -- I've no car (anag)" .)