Woman takes notice of nuance (5)
I believe the answer is:
shade
'nuance' is the definition.
(I've seen this before)
'woman takes notice' is the wordplay.
'woman' becomes 'she' (**).
'takes' is an insertion indicator.
'notice' becomes 'ad'.
'she' enclosing 'ad' is 'SHADE'.
'of' is the link.
(Other definitions for shade that I've seen before include "remains" , "See 15" , "Degree of colour" , "Quality of colour" , "Partial or comparative darkness" .)