Word of prayer in lamentations (4)
I believe the answer is:
amen
'word of prayer' is the definition.
(last word in a prayer)
'in lamentations' is the wordplay.
'in' says the answer is hidden in the clue.
'AMEN' is hidden in the letters of 'lamentations'.
(Other definitions for amen that I've seen before include "Response to prayer" , "Name for end to prayer" , "Churchgoer's assent?" , "I agree!" , "Prayerful last word" .)