Work from musical drama extremely tiresome (7)
I believe the answer is:
operate
'work' is the definition.
(synonyms)
'musical drama extremely tiresome' is the wordplay.
'musical drama' becomes 'opera' (an opera is a drama performed in music).
'extremely' suggests removing the centre (only the extremes of the word are used).
'tiresome' with its centre taken out is 'te'.
'opera'+'te'='OPERATE'
'from' acts as a link.
(Other definitions for operate that I've seen before include "Carry on business" , "effect" , "Perform as surgeon does" , "Cause to function" , "(Of machine) function" .)