Work on the wall leads to strike (6)
I believe the answer is:
wallop
'strike' is the definition.
(I've seen this before)
'work on the wall' is the wordplay.
'work' becomes 'op' (abbreviation for opus).
'on' means one lot of letters go next to another.
'op' put after 'wall' is 'WALLOP'.
'leads to' acts as a link.
(Other definitions for wallop that I've seen before include "Beat" , "ale?" , "Strike very hard" , "Thump" , "Best" .)