Work space at home has grand entrance (7)
I believe the answer is:
opening
'entrance' is the definition.
(I know that opening is a type of entrance)
'work space at home has grand' is the wordplay.
'work' becomes 'op' (abbreviation for opus).
'space' becomes 'en' (in printing, a space as wide as a letter 'n').
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'has' means one lot of letters go next to another.
'grand' becomes 'g' (G is short for grand as in a thousand).
'op'+'en'+'in'+'g'='OPENING'
(Other definitions for opening that I've seen before include "launch" , "Orifice; opportunity" , "Beginning, available job" , "Window of opportunity" , "Space, gap; beginning" .)