Worker with goddess holding the contrary (10)
I believe the answer is:
antithesis
'contrary' is the definition.
(thesaurus)
'worker with goddess holding the' is the wordplay.
'worker' becomes 'ant' (worker is a type of ant).
'with' means one lot of letters go next to another.
'goddess' becomes 'isis' (Egyptian god).
'holding' indicates putting letters inside.
'isis' going around 'the' is 'ithesis'.
'ant'+'ithesis'='ANTITHESIS'
(Other definitions for antithesis that I've seen before include "opposing view" , "Reverse" , "Opposite; contrasting idea" , "Contrast between two things" , "Opposition" .)