World of Don, Adam, Erica, somehow not close to sister (8)
I believe the answer is:
academia
'world of don' is the definition.
(don is a type of academic)
I don't understand how the rest of the clue works.
(Other definitions for academia that I've seen before include "scholastic life" , "The world of college or university" , "schools and universities" , "scholarly life" , "Teaching environment" .)