World-weariness (5)
I believe the answer is:
ennui
'world-weariness' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for ennui that I've seen before include "Feeling of weariness or boredom" , "Feeling of listlessness" , "doldrums" , "Effect of boredom" , "to make one list less when connected" .)