Worldly-wise Hoskins is one hot to open shaken-up lager tin (9)
I believe the answer is:
earthling
'worldly-wise hoskins is one' is the definition.
(in terms of worlds, the setter is an Earthling)
'hot to open shaken-up lager tin' is the wordplay.
'hot' becomes 'h' (abbreviation eg on taps).
'to open' is an insertion indicator (some letters create an opening in a word).
'shaken-up' is an anagram indicator.
'lager'+'tin'='lagertin'
'lagertin' is an anagram of 'eartling'.
'h' placed into 'eartling' is 'EARTHLING'.
(Other definitions for earthling that I've seen before include "Man of the world" , "Human being (sci-fi)" , "sci-fi character" , "man so to be called from space?" .)