Wounded setter guarding train depot's entrance (6)
I believe the answer is:
maimed
'wounded' is the definition.
(I know that wounded can be written as maimed)
'setter guarding train depot's entrance' is the wordplay.
'setter' becomes 'me' (the setter of the clue).
'guarding' indicates putting letters inside (inserted letters are protected or guarded).
'train' becomes 'aim' (synonyms).
'entrance' says to take the initial letters.
The first letter of 'depots' is 'd'.
'me' going around 'aim' is 'maime'.
'maime'+'d'='MAIMED'
(Other definitions for maimed that I've seen before include "Hurt" , "Wounded or injured, maybe disabled" , "Wounded and crippled" , "Mutilated, wounded" , "Injured so that a body-part is permanently damaged" .)