Wretchedly unhappy blame rise in disorder (9)
I believe the answer is:
miserable
'wretchedly unhappy' is the definition.
(I've seen this before)
'blame rise in disorder' is the wordplay.
'in disorder' indicates anagramming the letters.
'blame'+'rise'='blamerise'
'blamerise' is an anagram of 'MISERABLE'.
(Other definitions for miserable that I've seen before include "Wretched, pitiful" , "Wretched, doleful" , "Being sad" , "Wretched, low" , "Dreary - pathetic" .)