Yes, boy, makes gemstones weary (5)
I believe the answer is:
jades
'gemstones weary' is the definition.
I can't tell whether this defines the answer.
'yes boy' is the wordplay.
'yes' becomes 'ja' (I can't justify this - if you can you should give a lot more credence to this answer).
'boy' becomes 'Des' (short for Desmond).
'ja'+'des'='JADES'
'makes' acts as a link.
Can you help me to learn more?
(Other definitions for jades that I've seen before include "Worn-out horses" , "Worthless nags" .)