You and I air problem - to some extent tiring (9)
I believe the answer is:
wearisome
'tiring' is the definition.
(I've seen this in another clue)
'you and i air problem to some' is the wordplay.
'you and i' becomes 'we'.
'problem' indicates an anagram.
'to' says to put letters next to each other.
'air' with letters rearranged gives 'ari'.
'we'+'ari'+'some'='WEARISOME'
'extent' acts as a link.
This may not be right. It may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for wearisome that I've seen before include "pestilential" , "Trying" , "Boring" , "Tedious, tiring" , "Vexatious" .)