You and I left guide around start of route being knowledgeable (4-4)
I believe the answer is:
well-read
'being knowledgeable' is the definition.
('well-read' can be a synonym of 'knowledgeable')
'you and i left guide around start of route' is the wordplay.
'you and i' becomes 'we' (we means you and I).
'left' becomes 'l' (common abbreviation).
'guide' becomes 'lead' (lead can mean to usher or guide).
'around' means one lot of letters goes inside another.
'start of route' becomes 'r' (I can't explain this - if you can you should believe this answer much more).
'lead' placed around 'r' is 'lread'.
'we'+'l'+'lread'='WELL-READ'
Can you help me to learn more?
(Other definitions for well-read that I've seen before include "Erudite" , "Highly literate" , "A dweller may be knowledgeable about literature" , "Having good book knowledge" , "Literarily knowledgeable" .)