You don't say very much at home at any time (4,1,5)
I believe the answer is:
well i never
'you don't say' is the definition.
(both can be used to express disbelief)
'very much at home at any time' is the wordplay.
'very much' becomes 'well' (well can mean very much or to a great extent).
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'at any time' becomes 'ever' (synonyms).
'well'+'in'+'ever'='WELL I NEVER!'
(Other definitions for well i never that I've seen before include "Good gracious me!" , "that comes as a great shock" , "Always sick, me?" , "That surprises me!" , "Fancy that" .)