You may need these when arranging vacation in Santa Cruz, initially (12)

I believe the answer is:

vaccinations

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'you may need' is the definition.
I can't tell whether this definition defines the answer.

'these when arranging vacation in santa cruz initially' is the wordplay.
'these when arranging' is an anagram indicator.
'initially' says to take the initial letters.
The initial letters of 'santa cruz' is 'sc'.
'vacation'+'in'+'sc'='vacationinsc'
'vacationinsc' anagrammed gives 'VACCINATIONS'.

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I've seen this clue in The Telegraph.

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