Young men lose the head with condition briefly of Pearl's home (6)
I believe the answer is:
oyster
'young men lose the head' is the definition.
I can't tell whether this defines the answer.
'with condition briefly of pearl's home' is the wordplay.
'with' means one lot of letters goes inside another.
'condition' becomes 'sty' (sty is a kind of condition).
'briefly of' means to remove the last letter (I've seen 'briefly' mean this).
'pearl's home' becomes 'oyer' (I can't justify this - if you can you should give a lot more credence to this answer).
'sty' with its final letter taken off is 'st'.
'st' inserted within 'oyer' is 'OYSTER'.
Can you help me to learn more?
(Other definitions for oyster that I've seen before include "the world may be yours" , "bit of chicken meat" , "Bivalve shellfish" , "Secretive person; bivalve" , "Capital card" .)