Yours truly drained cloudy bitter (3)
I believe the answer is:
icy
'bitter' is the definition.
(thesaurus)
'yours truly drained cloudy' is the wordplay.
'yours truly' becomes 'I' (the person who set this crossword).
'drained' suggests removing the centre.
'cloudy' with its middle removed is 'cy'.
'i'+'cy'='ICY'
(Other definitions for icy that I've seen before include "frozen over!" , "Glacial" , "Freezing and slippy" , "(Of relations) very hostile" , "Very chilly" .)