Any gin? No? Awfully tiresome (8)
I believe the answer is:
annoying
'tiresome' is the definition.
(I've seen this before)
'any gin? no? awfully' is the wordplay.
'awfully' is an anagram indicator.
'any'+'gin'+'no'='anyginno'
'anyginno' with letters rearranged gives 'ANNOYING'.
(Other definitions for annoying that I've seen before include "Irritating, bothersome" , "It's galling" , "Vexatious" , "Irksome" , "Irking" .)