Asian river up there, as winding (9)
I believe the answer is:
euphrates
'asian river' is the definition.
(I've seen this before)
'up there as winding' is the wordplay.
'winding' indicates an anagram.
'up'+'there'+'as'='upthereas'
'upthereas' with letters rearranged gives 'EUPHRATES'.
(Other definitions for euphrates that I've seen before include "running water in SW Asia" , "Asian flower" , "some running water in Middle East" , "River joining the Tigris" , "River flowing through Turkey, Syria and Iraq" .)