Employment around Neath 40% down, creating anxiety (6)
I believe the answer is:
unease
'anxiety' is the definition.
(anxious or nervous condition)
'employment around neath' is the wordplay.
'employment' becomes 'use' (how something is used).
'around' means one lot of letters goes inside another.
'neath' becomes 'nea' (I can't justify this - if you can you should believe this answer much more).
'use' going around 'nea' is 'UNEASE'.
'40% down creating' acts as a link.
This may not be correct. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for unease that I've seen before include "State of worry and lack of confidence" , "Discomfort or apprehension" , "Disquiet" , "State of anxiety" , "Anxiety, discontent" .)