Fruit can make you no end fat! (4)
I believe the answer is:
plum
'fruit can make' is the definition.
'plum' can be an answer for 'fruit' (I've seen this before). I'm not certain of the 'can make' bit.
'no end fat' is the wordplay.
'no end' means to remove the last letter.
'fat' becomes 'plump' (synonyms).
'plump' with its final letter removed is 'PLUM'.
'you' acts as a link.
Can you help me to learn more?
(Other definitions for plum that I've seen before include "Lump of fruit" , "superior kind?" , "Damson-like fruit" , "Brilliant" , "Oval fruit with single hard stone" .)