Fuse is a nuisance (4)
I believe the answer is:
bind
This clue is a double definition.
'fuse' is the first definition.
(thesaurus)
'nuisance' is the second definition.
(I've seen this before)
'is a' acts as a link.
(Other definitions for bind that I've seen before include "Senior figure" , "Tie, fasten" , "Restrict" , "Impose a contractual obligation on (someone)" , "Wrap tightly - nuisance" .)