Guardian essentially loathes Republican with American support (7)
I believe the answer is:
trustee
'guardian' is the definition.
(trustee is a kind of guardian)
'essentially loathes republican with american support' is the wordplay.
'essentially' indicates the central letters.
'republican' becomes 'r' (abbreviation).
'with american' becomes 'us' (I am not sure about the 'with' bit.**).
'support' becomes 'tee' (I've seen this before).
The centre of 'loathes' is 't'.
't'+'r'+'us'+'tee'='TRUSTEE'
Can you help me to learn more?
(Other definitions for trustee that I've seen before include "Member of a fund's governing board" , "One with powers of administration over property" , "Legal agent" , "Person with legal ownership of property to be used solely for specified purposes" , "Person who holds and administers property for another - have faith in him" .)