In the morning, speaking with no sense of right or wrong (6)
I believe the answer is:
amoral
'no sense of right or wrong' is the definition.
(I've seen this in another clue)
'in the morning speaking' is the wordplay.
'in the morning' becomes 'am' (AM on a clock).
'speaking' becomes 'oral' (I can't justify this - if you can you should give a lot more credence to this answer).
'am'+'oral'='AMORAL'
'with' acts as a link.
Can you help me to learn more?
(Other definitions for amoral that I've seen before include "Lacking any ethical sense" , "outrageous!" , "Ignoring what's right and wrong" , "Lacking principles" , "Lacking sense of decency" .)