Make a home in Totnes today! (4)
I believe the answer is:
nest
'make a home' is the definition.
(I've seen this in another clue)
'in totnes today' is the wordplay.
'in' indicates the answer is hidden within the clue.
'NEST' is hidden within 'totnes today'.
(Other definitions for nest that I've seen before include "Snug retreat" , "Cosy place" , "Structure for laying eggs" , "Eyrie" , "10 [HOUSE]" .)