Man is one, despite what Donne says (6)
I believe the answer is:
island
'what donne says' is the definition.
I can't tell whether this defines the answer.
'man is one' is the wordplay.
I cannot really see how this works, but
'man' could be 'land' and 'land' is located in the answer.
'is' is present in the answer.
This accounts for all the letters.
This may be the basis of the clue (or it may be nonsense).
'despite' is the link.
Can you help me to learn more?
(Other definitions for island that I've seen before include "Christmas or Easter, perhaps?" , "Man, for example" , "It could follow desert, coral, thousand or traffic" , "Cuba is one" , "Body of land entirely surrounded by water" .)