Manage large snake accommodated in sweltering mobile home (9)
I believe the answer is:
houseboat
'mobile home' is the definition.
'manage large snake accommodated in sweltering' is the wordplay.
'manage' becomes 'use'.
'large snake' becomes 'boa' (I've seen this in another clue).
'accommodated in' indicates putting letters inside.
'sweltering' becomes 'hot' (similar in meaning).
'use'+'boa'='useboa'
'useboa' put into 'hot' is 'HOUSEBOAT'.
(Other definitions for houseboat that I've seen before include "home secured by the bank" , "vessel" , "Floating abode" , "Dwelling" , "home to keep afloat" .)