Refractoriness (13)
I believe the answer is:
recalcitrance
'refractoriness' is the definition.
(I know that refractoriness can be written as recalcitrance)
This is all the clue.
(Other definitions for recalcitrance that I've seen before include "Obstinacy" , "Strong objection or opposition" , "Wilfulness" , "stubborn opposition" .)