Sanctity affected sole and shin (8)
I believe the answer is:
holiness
'sanctity' is the definition.
(I know that sanctity can be written as holiness)
'affected sole and shin' is the wordplay.
'affected' is an anagram indicator.
'and' says to put letters next to each other.
'sole' after 'shin' is 'shinsole'.
'shinsole' with letters rearranged gives 'HOLINESS'.
(Other definitions for holiness that I've seen before include "Goodness!" , "State of sanctity" , "Piety" , "purity" , "State of spiritual excellence" .)