Spice in container brought up by Margaret (6)
I believe the answer is:
nutmeg
'spice' is the definition.
(I know that Nutmeg is a spice)
'container brought up by margaret' is the wordplay.
'container' becomes 'tun' (tun is a kind of container).
'brought up' says the letters should be written in reverse (in a down clue, letters go up).
'by' means one lot of letters go next to another.
'margaret' becomes 'meg' (short for Margaret).
'tun' backwards is 'nut'.
'nut'+'meg'='NUTMEG'
'in' is the link.
(Other definitions for nutmeg that I've seen before include "Hard seed of tropical tree grated for spice" , "spicy stuff" , "Asian tree whose aromatic seed is used as spice when grated or ground" , "Aromatic seasoning" , "Variety of spice" .)