Tricky maths with introduction of algebra leads to complaint (6)
I believe the answer is:
asthma
'complaint' is the definition.
(asthma is a medical complaint)
'tricky maths with introduction of algebra' is the wordplay.
'tricky' indicates an anagram.
'with' says to put letters next to each other.
'introduction of' suggests taking the first letters.
The initial letter of 'algebra' is 'a'.
'maths' anagrammed gives 'asthm'.
'asthm'+'a'='ASTHMA'
'leads to' acts as a link.
(Other definitions for asthma that I've seen before include "Breathing illness" , "inspiring trouble" , "Respiratory problem" , "Distressing breathing condition" , "which leaves one breathless" .)