Make an issue of something (4)
I believe the answer is:
emit
'make' is the definition.
The definition and answer can be both related to bodily activities as well as being verbs in their base form.
Maybe there's an association between them I don't understand?
'issue of something' is the wordplay.
'issue of' becomes 'em' (I can't explain this - if you can you should believe this answer much more).
'something' becomes 'it' (both can refer to an object).
'em'+'it'='EMIT'
'an' is the link.
Can you help me to learn more?
(Other definitions for emit that I've seen before include "Let out" , "Give off or discharge" , "Throw out" , "Exhale" , "Send forth" .)