Uncomfortable feeling one gets around hospital (4)
I believe the answer is:
ache
'uncomfortable feeling' is the definition.
(I've seen this in another clue)
'one gets around hospital' is the wordplay.
'one' becomes 'ace' (ace has a value of one in some card games).
'gets around' means one lot of letters goes inside another.
'hospital' becomes 'H' (abbreviation for hospital).
'ace' going around 'h' is 'ACHE'.
(Other definitions for ache that I've seen before include "Shakespearean character" , "Longing" , "yearning" , "Throb - hurt" , "painful" .)