Work a weekend at Aden, possibly (5)
I believe the answer is:
knead
'work' is the definition.
(synonyms)
'a weekend at aden possibly' is the wordplay.
'a weekend' becomes 'k' (I've seen this in other clues).
'at' means one lot of letters go next to another.
'possibly' indicates an anagram.
'aden' anagrammed gives 'nead'.
'k'+'nead'='KNEAD'
(Other definitions for knead that I've seen before include "Massage - naked (anag)" , "Work (dough) into mass" , "Work with finger movements" , "Massage with hands" , "Work flour into dough manually" .)