A game with many skills (5)
I believe the answer is:
darts
'a game' is the definition.
(I know that darts is a type of board game)
'with many skills' is the wordplay.
'with' is a charade indicator (letters next to each other).
'many' becomes 'd' (Roman numeral for 500).
'skills' becomes 'arts' (art can mean a skill or talent).
'd' next to 'arts' is 'DARTS'.
(Other definitions for darts that I've seen before include "They are thrown at targets in pubs" , "quick movements" , "Game with board and missiles" , "Traditional pub game" , "Tears" .)