A lack of reaction to the negative answer (2,8)

I believe the answer is:

no response

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'a lack' is the definition.
I don't know anything about this answer so I can't tell whether it can be defined by this definition.

'reaction to the negative answer' is the wordplay.
'reaction' becomes 'response' (synonyms).
'to' means one lot of letters go next to another (I've seen this in other clues).
'the negative answer' becomes 'no'.
'response' put after 'no' is 'NO RESPONSE'.

'of' is the link.

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I've seen this clue in the Evening Standard.

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