A leading lady and good Scots queen (6)
I believe the answer is:
guider
'a leading' is the definition.
Both the answer and definition are singular nouns.
Perhaps they are linked in a way I don't understand?
'lady and good scots queen' is the wordplay.
'lady' becomes 'gui'.
'and' is a charade indicator (letters next to each other).
'good scots queen' becomes 'der' (I am not sure about this - if you are sure you should believe this answer much more).
'gui'+'der'='GUIDER'
Can you help me to learn more?
(Another definition for guider that I've seen is " group leader".)