A measure of substance in unusual card game (8)
I believe the answer is:
decagram
'a measure of substance' is the definition.
'unusual card game' is the wordplay.
'unusual' indicates an anagram.
'card'+'game'='cardgame'
'cardgame' anagrammed gives 'DECAGRAM'.
'in' is the link.
(Another definition for decagram that I've seen is " The weight".)
I've seen this clue in The Times.
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