A point, going with twenty-two’s sport (3)
I believe the answer is:
run
'sport' is the definition.
(thesaurus)
'a point going with twenty-two's' is the wordplay.
'a point' becomes 'N' (North).
'going with' means one lot of letters go next to another.
'twenty two's' becomes 'ru' (I am not sure about this - if you are sure you should believe this answer much more).
'n' after 'ru' is 'RUN'.
Can you help me to learn more?
(Other definitions for run that I've seen before include "Discharge" , "Possibly an extra" , "A single" , "publish" , "stand" .)