A problem with migraine? (8)
I believe the answer is:
headache
This clue is a double definition.
'a problem' is the first definition.
(I've seen this before)
'migraine?' is the second definition.
(migraine is a kind of headache)
'with' is the link.
(Other definitions for headache that I've seen before include "Cause of worry or trouble" , "Migraine" , "trial" , "Worry, trouble (colloq.)" , "Cause of worry/trouble" .)