A sign of losing? (5)
I believe the answer is:
minus
'a sign' is the definition.
(minus sign is a kind of sign)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for minus that I've seen before include "deficiency" , "(Of temperature) below zero" , "Lacking; below zero" , "Disadvantage" , "Take-away (sign)" .)