Abandon hope as pride is knocked (7)
I believe the answer is:
despair
'abandon hope' is the definition.
('despair' can be a synonym of 'abandon hope')
'as pride is knocked' is the wordplay.
'is knocked' indicates an anagram.
'as'+'pride'='aspride'
'aspride' is an anagram of 'DESPAIR'.
(Other definitions for despair that I've seen before include "Praised (anag) - lose hope" , "gloom" , "Hopeless" , "An unhappy state" , "Abandon hope" .)